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KMID : 0614620170690050278
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Korean Journal of Gastroenterology
2017 Volume.69 No. 5 p.278 ~ p.282
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Elevated Gastric Antrum Erosions in Portal Hypertension Patients: Peptic Disease or Mucosal Congestion?
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Conejo Fernanda Cordeiro de Azevedo
Fracassi Mabel Tatty Medeiros
Assef Mauricio Saab
Ribeiro Mauricio Alves
Szutan Luiz Arnaldo
Ferreira Fabio Goncalves
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Abstract
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Background/Aims: Portal hypertension (PH) is a syndrome characterized by chronic increase in the pressure gradient between the portal vein and inferior vena cava. Previous studies have suggested an increased frequency of antral elevated erosive gastritis in patients with PH, as well as an etiologic association; however, there has not been any histological evidence of this hypothesis to date. Our aim was to evaluate the histological features found in elevated antral erosions in patients with portal hypertension.
Methods: Sixty-nine patients were included; 28 with and 41 without PH. All patients underwent endoscopy, and areas with elevated antral erosion were biopsied.
Results: In the PH group, 24 patients had inflammatory infiltration with or without edema and vascular congestion, and 4 patients had no inflammation. In the group without PH, all patients showed inflammatory infiltration of variable intensity. There was no statistical significance between the two groups in the presence of Helicobacter pylori. There as a histological similarity between the two groups, if PH patients without inflammation were excluded; however, more edema and vascular congestion were observed in the PH group (p=0.002).
Conclusions: The findings show that elevated antral erosions in patients with PH have more evident edema and vascular congestion in addition to lymphocytic infiltration.
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KEYWORD
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Hypertension, portal, Gastritis, Gastric antral vascular ectasia, Lymphocytes, Edema
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